Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Isl2  insulin related protein 2 (islet 2)   (Synonyms: 3110001N10Rik, islet 2, islet-2)
Results	Reference
1	J:184160 Abdo H, Li L, Lallemend F, Bachy I, Xu XJ, Rice FL, Ernfors P, Dependence on the transcription factor Shox2 for specification of sensory neurons conveying discriminative touch. Eur J Neurosci. 2011 Nov;34(10):1529-41
1	J:158712 Bassett EA, Williams T, Zacharias AL, Gage PJ, Fuhrmann S, West-Mays JA, AP-2alpha knockout mice exhibit optic cup patterning defects and failure of optic stalk morphogenesis. Hum Mol Genet. 2010 May 1;19(9):1791-804
1	J:330829 Cabirol MJ, Cardoit L, Courtand G, Mayeur ME, Simmers J, Pascual O, Thoby-Brisson M, Microglia shape the embryonic development of mammalian respiratory networks. Elife. 2022 Nov 2;11:e80352
1	J:284139 Chaimowicz C, Ruffault PL, Cheret C, Woehler A, Zampieri N, Fortin G, Garratt AN, Birchmeier C, Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse. Development. 2019 Sep 6;146(17):dev174045
1	J:268047 Cheng I, Jin L, Rose LC, Deppmann CD, Temporally restricted death and the role of p75NTR as a survival receptor in the developing sensory nervous system. Dev Neurobiol. 2018 Jul;78(7):701-717
1	J:257926 Collinson JM, Lindstrom NO, Neves C, Wallace K, Meharg C, Charles RH, Ross ZK, Fraser AM, Mbogo I, Oras K, Nakamoto M, Barker S, Duce S, Miedzybrodzka Z, Vargesson N, The developmental and genetic basis of 'clubfoot' in the peroneal muscular atrophy mutant mouse. Development. 2018 Feb 8;145(3):dev160093
1	J:132705 De Marco Garcia NV, Jessell TM, Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity. Neuron. 2008 Jan 24;57(2):217-31
1	J:213791 Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, Brown CW, John GR, Combinatorial actions of Tgfbeta and Activin ligands promote oligodendrocyte development and CNS myelination. Development. 2014 Jun;141(12):2414-28
1	J:262472 Edmond M, Hanley O, Philippidou P, Topoisomerase IIbeta Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs. eNeuro. 2017 Nov-Dec;4(6):ENEURO.0404-17.2017
1*	J:63172 Erskine L, Williams SE, Brose K, Kidd T, Rachel RA, Goodman CS, Tessier-Lavigne M, Mason CA, Retinal ganglion cell axon guidance in the mouse optic chiasm: expression and function of robos and slits. J Neurosci. 2000 Jul 1;20(13):4975-82
1	J:250440 Ferguson R, Serafeimidou-Pouliou E, Subramanian V, Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation. J Anat. 2016 Dec;229(6):871-891
1	J:158231 Francius C, Clotman F, Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development. Neuroscience. 2010 Jan 13;165(1):116-29
1*	J:65601 Garel S, Garcia-Dominguez M, Charnay P, Control of the migratory pathway of facial branchiomotor neurones. Development. 2000 Dec;127(24):5297-307
1	J:78726 Genoud S, Lappe-Siefke C, Goebbels S, Radtke F, Aguet M, Scherer SS, Suter U, Nave KA, Mantei N, Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol. 2002 Aug 19;158(4):709-18
1*	J:148194 Han DY, Kobayashi M, Nakano M, Atobe Y, Kadota T, Funakoshi K, Differential Islet-1 expression among lumbosacral spinal motor neurons in prenatal mouse. Brain Res. 2009 Apr 10;1265:30-6
1	J:315755 Hancock ML, Nowakowski DW, Role LW, Talmage DA, Flanagan JG, Type III neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery. Development. 2011 Nov;138(22):4887-98
1*	J:62985 Helmbacher F, Schneider-Maunoury S, Topilko P, Tiret L, Charnay P, Targeting of the EphA4 tyrosine kinase receptor affects dorsal/ventral pathfinding of limb motor axons. Development. 2000 Aug;127(15):3313-24
1	J:85445 Herrera E, Brown L, Aruga J, Rachel RA, Dolen G, Mikoshiba K, Brown S, Mason CA, Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell. 2003 Sep 5;114(5):545-57
1	J:215576 Itoh T, Horiuchi M, Ikeda RH Jr, Xu J, Bannerman P, Pleasure D, Penninger JM, Tournier C, Itoh A, ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. J Neurosci. 2014 Aug 6;34(32):10729-42
1*	J:54064 Kablar B, Rudnicki MA, Development in the absence of skeletal muscle results in the sequential ablation of motor neurons from the spinal cord to the brain. Dev Biol. 1999 Apr 1;208(1):93-109
1	J:256120 Kuwajima T, Soares CA, Sitko AA, Lefebvre V, Mason C, SoxC Transcription Factors Promote Contralateral Retinal Ganglion Cell Differentiation and Axon Guidance in the Mouse Visual System. Neuron. 2017 Mar 8;93(5):1110-1125.e5
1	J:165487 Magnani D, Hasenpusch-Theil K, Jacobs EC, Campagnoni AT, Price DJ, Theil T, The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence. J Neurosci. 2010 Oct 13;30(41):13883-94
1	J:220860 Magnani D, Morle L, Hasenpusch-Theil K, Paschaki M, Jacoby M, Schurmans S, Durand B, Theil T, The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
1	J:295965 Miesfeld JB, Ghiasvand NM, Marsh-Armstrong B, Marsh-Armstrong N, Miller EB, Zhang P, Manna SK, Zawadzki RJ, Brown NL, Glaser T, The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell development. Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21690-21700
1	J:210605 Molofsky AV, Kelley KW, Tsai HH, Redmond SA, Chang SM, Madireddy L, Chan JR, Baranzini SE, Ullian EM, Rowitch DH, Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 8;509(7499):189-94
1	J:76659 Muller T, Brohmann H, Pierani A, Heppenstall PA, Lewin GR, Jessell TM, Birchmeier C, The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord. Neuron. 2002 May 16;34(4):551-62
1	J:264453 Newbern JM, Li X, Shoemaker SE, Zhou J, Zhong J, Wu Y, Bonder D, Hollenback S, Coppola G, Geschwind DH, Landreth GE, Snider WD, Specific functions for ERK/MAPK signaling during PNS development. Neuron. 2011 Jan 13;69(1):91-105
1	J:328038 Niu F, Che P, Yang Z, Zhang J, Yang L, Zhuang M, Ou X, Ji SJ, m(6)A regulation of cortical and retinal neurogenesis is mediated by the redundant m(6)A readers YTHDFs. iScience. 2022 Sep 16;25(9):104908
1	J:39370 Ozaki S, Snider WD, Initial trajectories of sensory axons toward laminar targets in the developing mouse spinal cord. J Comp Neurol. 1997 Apr 7;380(2):215-29
1	J:197494 Philippidou P, Walsh CM, Aubin J, Jeannotte L, Dasen JS, Sustained Hox5 gene activity is required for respiratory motor neuron development. Nat Neurosci. 2012 Dec;15(12):1636-44
1	J:176573 Ramanantsoa N, Hirsch MR, Thoby-Brisson M, Dubreuil V, Bouvier J, Ruffault PL, Matrot B, Fortin G, Brunet JF, Gallego J, Goridis C, Breathing without CO2 Chemosensitivity in Conditional Phox2b Mutants. J Neurosci. 2011 Sep 7;31(36):12880-8
1	J:159386 Shibasaki K, Murayama N, Ono K, Ishizaki Y, Tominaga M, TRPV2 enhances axon outgrowth through its activation by membrane stretch in developing sensory and motor neurons. J Neurosci. 2010 Mar 31;30(13):4601-12
1	J:81762 Stenman J, Yu RT, Evans RM, Campbell K, Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. Development. 2003 Mar;130(6):1113-22
1	J:84301 Stolt CC, Lommes P, Sock E, Chaboissier MC, Schedl A, Wegner M, The Sox9 transcription factor determines glial fate choice in the developing spinal cord. Genes Dev. 2003 Jul 1;17(13):1677-89
1	J:124714 Subramanian V, Feng Y, A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis. Hum Mol Genet. 2007 Jun 15;16(12):1445-53
1	J:206855 Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T, CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. J Neurosci. 2014 Jan 22;34(4):1370-9
1	J:152560 Thoby-Brisson M, Karlen M, Wu N, Charnay P, Champagnat J, Fortin G, Genetic identification of an embryonic parafacial oscillator coupling to the preBotzinger complex. Nat Neurosci. 2009 Aug;12(8):1028-35
1*	J:45780 Tiret L, Le Mouellic H, Maury M, Brulet P, Increased apoptosis of motoneurons and altered somatotopic maps in the brachial spinal cord of Hoxc-8-deficient mice. Development. 1998 Jan;125(2):279-91
1	J:111725 Williams ME, Lu X, McKenna WL, Washington R, Boyette A, Strickland P, Dillon A, Kaprielian Z, Tessier-Lavigne M, Hinck L, UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. Nat Neurosci. 2006 Aug;9(8):996-8
1	J:336860 Wurmser M, Madani R, Chaverot N, Backer S, Borok M, Dos Santos M, Comai G, Tajbakhsh S, Relaix F, Santolini M, Sambasivan R, Jiang R, Maire P, Overlapping functions of SIX homeoproteins during embryonic myogenesis. PLoS Genet. 2023 Jun;19(6):e1010781